Comparative Effectiveness of Human Papillomavirus Vaccination Against Cervical Abnormalities by Dose Level in a Cohort of Privately-Insured U.S. Girls

Human papillomavirus (HPV) vaccines prevent infection with the most cancer-causing HPV types. However, many age-eligible girls do not initiate or complete the three-dose regimen. There is limited information on the magnitude of protection provided by partial-vaccination. We sought to empirically estimate the effect of HPV vaccination by dose (0, 1, 2 or 3) on cervical abnormality rates in a screening cohort of privately-insured U.S. girls (N=234,829).